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Doses Per Vial Vial duration varies by dose escalation phase: 3mg vial: At 0.25mg/week = 12 weeks At 0.5mg/week = 6 weeks At 1mg/week = 3 weeks At 2.4mg/week = 1.25 weeks 5mg vial: At 0.25mg/week = 20 weeks At 0.5mg/week = 10 weeks At 1mg/week = 5 weeks At 1.7mg/week = ~3 weeks At 2.4mg/week = ~2 weeks A 5mg vial can cover the entire first 4 months of a slow escalation protocol starting at 0.25mg

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Massive inflammatory reaction is observed when there is a dysregulated ratio of pro-inflammatory to anti-inflammatory cytokines (Figure 1 and Figure 2) [6,27]