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They derive from the nucleophilic addition of water to the thiolhemin adducts while a pyrrole ring is being formed, leaving the iron bonded to three nitrogens, in this case

KEAP1 mutations, however, are widely distributed in the KEAP1 gene and are found in virtually all domains of the protein

Lee S, Lee SM, Lee SH, Choi W-K, Park S-J, Kim DY
