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If a beta-blocker is combined, a vasodilator beta-blocker, including Carvedilol or Nebivolol, may be preferred because non-vasodilator beta-blockers accelerate albuminuria progression ( In patients with DKD, SGLT2i or MRA can be added when the target urinary albumin levels are not achieved with RAS blockade (Piperidou et al., 2019)
Its also widened the types of groups who now use them
Advances in imaging the brain-gut axis: functional gastrointestinal disorders
