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A new review by Sebastin Zagmutt Caroca PhD, Biotechnology Rosalia Rodriguez Rodriguez et al proposes a compelling framework positioning chronic hypothalamic microinflammation as an initiating eventnot a downstream consequenceof systemic metabolic dysfunction and #obesity

Moreover, these alterations may contribute to increased anxiety, reduced self-control, and a greater propensity for impulsive or dominant behaviours, particularly in individuals with pre-existing traits such as poor impulse regulation or antisocial tendencies (59, 60)

Astragaloside inhibits IL-1-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice

Moreover, WS is a safe drug and there have been no observations of hepatotoxicity by WS in clinical trials (Paramadhas and Alagirisamy, 2016)