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Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty A case series

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The mRNA transcripts regulating spermatogenesis (e.g., ODF2 and SPATA18 ), nuclear genome structure (e.g., PRM1 , OAZ3 , HSPB9 , and NDUFS4 ), mitochondrial function ( e.g., COX1ATP8 ), and fertilization (e.g., HSPA1L and PRSS37 ) were observed to be associated with compaction of sperm chromatin, energy metabolism, oxidative stress, apoptosis, and early embryo development (Sendler et al., 2013