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Propionyl L-Carnitine supports cardiovascular health and helps reduce fatigue

While the ob/ob model appears to phenotypically recapitulate several aspects of human HFpEF, their clinical applicability is limited in two ways

When oxygen availability is limited, glucose is the most metabolically efficient fuel, and during myocardial ischemia, the ratio of acetyl-CoA/CoA in mitochondria increases, leading to the activation of pyruvate dehydrogenase (PDH) kinase, which in turn phosphorylates PDH to inhibit its activity
