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Hnatyszyn, H
Multiple sclerosis Multiple sclerosis is an autoimmune disease of unknown etiology that is characterized by the progressive destruction of myelin and nerve fibers in the central nervous system, causing neurological symptoms in affected individuals (85)
In addition, macrophages secrete sphingomyelinase, which has been reported to act synergistically with LPL to promote binding of LDL and lipoprotein (a) (Lp(a)) to vascular smooth muscle cells (VSMC) and the extracellular matrix promoting their retention in the artery (239,240)
