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This event is thoroughly documented clinically and leads to suppression of the levels of LH, FSH, and sex steroids and inhibition of the growth of prostatic and breast cancers, as reviewed in Schally et al

Maclean, K

Wang S.-P

It can be triggered by photo exposure, pregnancy, hormonal changes and medications, but its pathogenesis is not completely understood, reflected in the frequent recurrence after treatment.1, 2 Oxidative stress, caused by external factors such as exposure to solar radiation, sleep disorders, pollution, skin inflammation and emotional stress, can induce and perpetuate melanogenesis regardless of ultraviolet irradiation