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Yes when given under medical supervision, B12 injections are generally safe and well-tolerated

Underlying health conditions : In rare cases, complications have been reported with high-dose B12 injections in people with certain heart conditions
Observational studies have associated alterations in cortisol patterns, such as flattened diurnal curves or elevated evening levels, with obesity, metabolic syndrome, and cardiovascular risk, though these findings do not establish causality
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