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The oxidative-defence pathway: natures shield The three major endogenously produced enzymatic antioxidants: superoxide dismutase (SOD), catalase and glutathione peroxidase, provide a primary defence system against cellular damage by removing free radicals as they are produced during metabolic reactions

About this article Cite this article Jurkowska, H., Stipanuk, M.H., Hirschberger, L.L

Chronic Stress: High levels of cortisol (the stress hormone) can drain antioxidant reserves as the body attempts to manage the physiological impact of a busy lifestyle

Several transcription factors such as activator protein (AP-1), nuclear factor kappa B (NF-B), and predominantly the nuclear factor erythroid 2related factor 2 (Nrf2) are involved in the induction of antioxidant enzymes