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Fis1, mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
The synaptopathy-induced excessive release of glutamate is amplified by the pathological transmitter-immunity cycle, which results in a pathophysiological switching from functional disorders to cell death
The HPV16 E7 oncoprotein directly suppresses the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, significantly reducing the expression of genes that encode type I interferon and pro-inflammatory proteins, hence facilitating immune evasion in several HPV-related tumors in murine models (Luo et al., 2020)
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