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Chung KM, Park H, Jung S, Ha S, Yoo SJ, Woo H, et al
Rubbia-Brandt et al (2) reported that 78% of patients with metastatic colorectal cancer receiving OXA-based chemotherapy experience varying degrees of sinusoidal injury to the liver

In an environment of energy stress, mTORC1 becomes continuously and abnormally active, driving unnecessary protein and lipid synthesis, which exacerbates the metabolic burden on cells

* Limitation: Most medications provide temporary relief and come with side effects, making them a band-aid rather than a long-term solution
