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The PDI active-site disulfide bonds are believed to be regenerated by chemical reaction of the protein with GSSG

Advances in the role of epigenetics in homocysteine-related diseases

Additionally, studies have examined how a lack of melatonin affects specific brain functions, such as the regulation of sphingolipid turnover in the hippocampus, which suggests that melatonin is involved in maintaining a balance of lipids, and that this equilibrium may be compromised in aging organisms (Tchekalarova et al

Compared to nuclear DNA, mtDNA lacks histone protection, has limited repair capacity, and is more prone to mutation, with a mutation rate approximately 1020 times higher than that of nuclear DNA (79)