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Meanwhile, the activity of other immune cells, such as macrophages and natural killer (NK) cells also reduces to accelerate the development of suppressive TME (Nguyen and Cho, 2025)

Ju HQ, Lin JF, Tian T, Xie D, Xu RH (2020) NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications

Science 314:130133 Held A, Adler M, Marques C et al (2023) iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons

If the body has insufficient antioxidants to neutralize the free radicals, the free radicals cause oxidative stress that can injure or destroy cells