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The shielding of reaction intermediates from the bulk solution by tunneling between the active sites and the complex allosteric coupling of the bound subunits have been the subject of many structural and mutagenesis studies
doi: 10.1016/j.dci.2019.02.006
The analysis only assessed the short-term risk
The phase 1 metabolism of amphetamine analogs is catalyzed by two systems: cytochrome P450 and flavin monooxygenase
