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Experimental work demonstrates that NGF upregulates leukocyte adhesion pathways and facilitates monocyteendothelium interactions while skewing macrophage phenotype, providing a plausible route to TAM accumulation and function in OS (4850)

Supplementation with propionate, AHR ligands and orally delivered antigens can induce T reg cells via gut dendritic cells that are specifically conditioned by gut epithelial cells and microbiota 299,300

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