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The methylation status of the SDC2 promoter in blood samples can be detected using the methylation quantitative endonuclease resistance DNA assay (MethyQESD)

Short-chain fatty acids (SCFAs), which are the products of microbial fermentation, act as substrates for enterocytes
(see comment by Gonzalo Otazu) "Epigenetics Paper Raises Questions"

[1] [2] The pharmacological effects of tirzepatide create unique nutritional considerations