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Individual cognitive outcomes associated with this variant have been observed with deficits of hippocampal plasticity, as well as concomitant with greater risks for general cognitive impairment and affective disorder [296,297]

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During aging and aging-related pathological contexts, excessive activation of mTORC1 signaling in the liver directly inhibits the transcriptional activity of peroxisome proliferator-activated receptor alpha (PPAR), a key regulator of ketone body production (Sengupta et al., 2010)

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