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DOI: 10.1016/s0891-5849(00)00317-8 87

Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

This signaling pathway is essential for the hypertrophic effects of IGF-1.23 Notably, IGF-1 has also been shown to promote intracellular lipid accumulation in mesangial cells, a phenotype similar to foam cells, which leads to reduced contractility in response to angiotensin-II.24,25 Furthermore, kidney samples from patients with advanced CKD and mouse models with renal fibrosis have defective fatty acid oxidation and higher lipid accumulation than controls without fibrosis

Gut microbiota, immune system, and bone