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Description
Early reports of sulfur intolerance largely stem from food-based additives (e.g., sulfites) associated with asthmatic reactions, diarrhea, hypotension, dermatitis, hives, and even anaphylaxis

Blood 100:329a, 2002

Thus, the holoenzyme is catalytically more efficient and less subject to inhibition by GSH than GCLC alone

The clinical success of iron chelation in this context validated the principle of targeting toxic iron overload
