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In these patients, mixed agonist/antagonist and partial agonist analgesics may reduce the analgesic effect and/or precipitate withdrawal symptoms [see PRECAUTIONS;Drug Interactions]

Note: Phase 2 trials also tested a 1 mg starting dose, which showed modest results

Spontaneous fungal peritonitis: A severe complication in patients with advanced liver cirrhosis

A 2.5 mg track has short direct data and real-world support for stable maintainers, but no long-duration maintenance trial. Continuing tirzepatide holds weight far better than stopping
