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Compared with the placebo group, the experimental group (receiving 500 mg of daily magnesium supplementation) showed improvements in sleep efficiency, sleep duration, sleep onset latency, and early-morning awakening frequency.82 A study performed on rats revealed a strong correlation between forebrain magnesium concentration and sleep duration.39 A recent systematic review, encompassing 7582 participants from 9 published cross-sectional, cohort, and randomized controlled studies, also identified an association between magnesium status and sleep quality.83 The findings demonstrated that in healthy adults, higher magnesium intake was correlated with various sleep quality parameters, including daytime sleepiness, drowsiness, snoring, and sleep duration

doi: 10.3390/molecules26237407 156 ZhaiZ.ZhangX.DingY.HuangZ.LiQ.ZhengM.et al

Ongoing clinical trials are currently investigating a single-dose regimen of Danuglipron for managing overweight and obesity (NCT04616339)

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