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It's not meant to be long-term, as it can limit fiber and beneficial prebiotics

The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
After this, it sends a signal to the anterior pituitary gland to secrete gonadotropin hormones: luteinising hormone (LH) and follicle-stimulating hormone (FSH)

revealed that the inhibition of PTEN via the activation of the PI3K/AKT pathway attenuated endoplasmic reticulum stress and apoptosis in APP/PS1 transgenic AD model mice [16]