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Oxidative stress can render tumor cells insensitive to anti-proliferative signals, apoptosis, and anchorage-independent growth, which alters tumor cell invasion and migration through epigenetic and metabolic mechanisms, further contributing to colorectal cancer development and progression (Ziczuk et al., 2020)

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The challenge, however, has been to raise circulating KB levels by using a palatable diet without significant elevated concentrations of plasma cholesterol and free fatty acids (FA)