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14 , 19 , 20 The largest published study reports the prevalence of factor V Leiden to be 44% among 119 women with a history of pregnancy-related venous thromboembolism compared with a rate of 7.7% among 233 age-matched women (relative risk 15.2)

Laskowski RA, MacArthur MW, Moss DS and Thornton JM: PROCHECK: A program to check the stereochemical quality of protein structures
