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By facilitating the removal of protein aggregates, paeoniflorin may reduce one source of toxicity in PD

This recognition step triggers further cytokine release and inflammation, thereby perpetuating an inflammationferroptosisinflammation positive feedback loop (138)

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It has been efficient in increasing the TDDs with varying molecular weights including small (fentanyl, orcalcein) to high molecular weight drugs weighing up to 40 kDa
