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En modelos animales preclnicos, dado su carcter de molcula pequea oral-activa, los diseos han contemplado dosificacin por va oral o intraperitoneal segn el protocolo aprobado por el comit de tica institucional, con esquemas de administracin diaria y ventanas de tratamiento que abarcan varias semanas para observar efectos sobre composicin corporal

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Likewise, the inhibition of catabolic pathways (IL-6, TNF-alpha), balanced with the stimulation of anabolic pathways (FoxO3a, p-AKT, p-mTOR, and P-GSK-3), has occurred in the counteraction of tumor-induced cachexia [56]