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Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

In Japan, JCR Pharmaceuticals launched remestemcel-L, which received market authorization under the brand name Temcell

[DOI] [PubMed] [Google Scholar] 549.Leonardini A., Laviola L., Perrini S., Natalicchio A., Giorgino F