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This process is mediated by glutaredoxins (GLRXs, also known as GRXs), which catalyze both glutathionylation and deglutathionylation, as well as by sulfiredoxins (SRXs) 9,10

also known as thioctic acid), is a naturally occurring dithiol compound synthesized by intestinal bacteria as well as being synthesized in the mitochondria

Reduced renal function decreases creatinine clearance and elevates circulating creatinine, a central biomarker of kidney dysfunction

developed mitochondrial-targeting paclitaxel liposomes that selectively accumulate in mitochondria, overcoming resistance in cisplatin-resistant A549 cells by promoting Bax activation and suppressing Bcl- 2 (Zhou et al