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Another strategy relies on inhibition of the glycine transporter (sarcosine, bitopertin) or of D-amino acid oxidase (DAAO), the enzyme that metabolizes D-serine (sodium benzoate)
10.1038/s41467-017-00901-0 20 ChenP.YangM.WangY.GuoY.LiuY.FangC.et al (2022)
The antiepileptic valproate also acts indirectly on the GABAergic system by blocking the metabolism of GABA and by blocking GABA reuptake, increasing GABA levels in the brain (Janmohamed et al., 2020)
