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In vitro drug release studies in simulated intestinal fluid (SIF) and gastric fluids (SGF) revealed that over 80% of the two drugs were released within 5 h in SGF, with a sustained release observed up to 24 h in SIF
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For this reason, MEL and its metabolites may serve as effective therapeutic agents in iron-induced oxidative stress, for example, in patients with Parkinsons and Alzheimers disease, in whom higher levels of iron and lipid peroxidation have been observed in the brain compared to healthy individuals [76,77]
