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In the early stage, the viral nonstructural protein 1 (NS1) inhibits type I interferon production and activates the PI3K-AKT (Protein Kinase B, PKB) pathway to suppress apoptosis ( At later stages, pro-apoptotic pathways are activated in a mitochondria-centered manner

A Speculative Scenario of VitB12 Deficiency Though lacking precise pathological studies, considering our current understanding of physiological pathways, it is possible to speculate on additional biochemical implications of VitB12 deficiency that may affect molecular and cellular processes (Figure 2)

MorroniFSitaGGraziosiATurriniEFimognariCTarozziAet al
