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glutathione peroxidase trace element (GPx) redox cycle. The main reaction that Selenocysteine containing Glutathione peroxidase biosynthesis
Description
(1997) WNTs modulate cell fate and behavior during vertebrate development
As a specialized glutathione peroxidase containing selenocysteine substituting cysteine, GPx4 plays an irreplaceable role in maintaining cell membrane integrity and protecting cells from oxidative damage by specifically reducing phospholipid hydroperoxides

Brooks, A

However, it is known that GSH is contra-indicated for other chemotherapy agents, such as for cisplatin, where GSH supplementation inhibits the action of cisplatin
