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In terms of innovation, among the novel drugs approved by the FDA this year, a total of 27 are "first-in-class" therapies , accounting for 54% (27/50) of the total number of new drugs approved in 2021

[DOI] [PubMed] [Google Scholar] 255.Small G.W., Siddarth P., Li Z., Miller K.J., Ercoli L., Emerson N.D., Martinez J., Wong K.P., Liu J., Merrill D.A., et al

Reduced-frequency alternatives are practitioner-derived, built on pharmacokinetic reasoning: GHK-Cu has a short circulating half-life, but its tissue remodeling effects are cumulative

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