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That is, a genetic predisposition, an environmental injury (e.g., surgical trauma), and psychological distress can converge and synergistically drive maladaptive neuroplasticity and disrupt homeostatic systems, thereby facilitating the transition from acute nociception to a persistent chronic pain state

259 Furthermore, endotoxin dose-dependent switch of NAD + biosynthesis pathways from NAMPT-dependent salvage to IDO1-dependent de novo biosynthesis maintains the nuclear NAD + pool, which promotes SIRT1-directed epigenetic regulation of immune tolerance

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GST amino acids sequences from all the selected species for phylogenetic analysis