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Apart from -synuclein, Lewy bodies also contain many other aggregated cellular proteins, which together constitute an interactome to promote fibrillation of -synuclein ( Under normal physiological conditions -synuclein exists mostly in an N acetylated membrane bound form which results in adoption of an -helical structure (Runfola et al., 2020)

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Growth hormone (GH) binds to the GH receptor (GHR) and induces the JAK2/STAT5 pathway to activate the synthesis of insulin-like growth factor 1 (IGF1)

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