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As electrons pass through the ETC complexes, protons are pumped from the mitochondrial matrix into the intermembrane space (IMS), creating a transmembrane electrical potential that is used to drive ATP production by ATP synthase (Complex V)
Protection against aminoglycoside ototoxicity has also been demonstrated by a wide array of antioxidants (e.g., lipoic acid, Coenzyme Q10, vitamin E) [150,151]
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J Neurosci 37(9):24712484 Kalkandelen S, Selimolu E, Erdoan F, Unc H, Alta E (2002 Jul-Aug) Comparative cochlear toxicities of streptomycin, gentamicin, amikacin and netilmicin in guinea-pigs
