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Nerinetide (NA-1) is a polypeptide that interferes with postsynaptic density protein 95 (PSD-95) and reduces the interaction between PSD-95 and neuronal nitric oxide synthase, thereby reducing nitric oxide radical production and its mediated cell death [59]
Accordingly, this pilot study was designed to examine the effects of tianma on the proteome metabolism in differentiated mouse neuronal N2a cells using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach
A significant factor that influences this is hydration
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