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Hirsch FR, et al

It includes a broad range of vital functions such as storage of material absorbed from the digestive tract, hormone catabolism, synthesis of different compounds like clotting factors, globulin, and albumin and detoxification reactions

IGF-1 LR3 accelerates cellular repair, stimulates satellite cells, and increases nutrient utilization

Additionally, the genetic defect impairs normal neural crest cell migration into the branchial arches, causing craniofacial anomalies and severe conotruncal cardiac defects (interrupted aortic arch) that may require immediate palliative interventions like balloon septostomy