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NPJ Aging 9 , 7 (2023)

These enzymes may be sourced from lysine degrading bacteria as d-2HG occurs as intermediate in some of these pathways, e.g., in E
More recently, the gut microbiome has been shown to be a significant source of octadecanoid biosynthesis, providing additional biosynthetic routes including hydratase activity (e.g., CLA-HY, FA-HY1, FA-HY2)

The evolution of ketosis: potential impact on clinical conditions
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