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Kouidrat Y, Pizzol D, Cosco T, et al

Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFR and bioenergetic mechanisms

Excessive oxidative stress may serve as an early warning system for a variety of illnesses

Treatment of cells with supplemental iron results in an increase in the HIF hydroxylase activity, while iron chelation produces the opposite effect ( Cultured human cells lacking PCBP1 or PCBP2 exhibit nuclear accumulation of active HIF1, which increases in cells made mildly or transiently iron deficient ( The activity of FIH1, also an iron- and oxygen-dependent HIF1 regulator, is dependent on PCBP1 as well ( Other classes of iron metalloenzymes may also depend on iron delivery by PCBPs