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Experimental studies further show that these fibrils are structurally stable and highly neurotoxic, their introduction into the colon reproduced key motor and cognitive deficits associated with PD [134, 135], underscoring the role of secretase as a molecular link between peripheral inflammation and central neuropathology
& Leckman, J
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Given its physicochemical characteristics, its topical administration becomes challenging, and it is necessary to develop new technological strategies to overcome the skin intact barrier
