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doi: 10.1016/0024-3205(96)00066-5

Abstract MM cells express high levels of CD38, while CD38 is expressed at relatively low levels on normal lymphoid and myeloid cells, and in some non-hematopoietic tissues

As research advances, the antioxidant system has progressively been categorized into two distinct types: those dependent on GPX4 and those independent of GPX4, which will be detailed below

Furthermore, a deficiency in Zip7 shifts macrophage activation towards an M2 phenotype, as evidenced by increased expression of the M2 marker CD206 and reduced levels of the M1 marker NOS2, along with lower production of proinflammatory cytokines such as TNF- and IL-6