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Description
However, these treatments often rely on enema or oral administration, which generally suffers from limited rectal retention time, insufficient local drug exposure, or low systemic bioavailability, thus limiting efficacy stability and patient compliance [7, 9]

C.SanjustE

doi: 10.3389/fnsys.2022.1059421 [DOI] [PMC free article] [PubMed] [Google Scholar] 45.Jeon YS, Yu S, Kim C, et al

Some patients see more dramatic effects
