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However, in the mouse brain, L-carnitine supplementation has been shown to increase brain 5-HT concentration ( 10 , increased low peripheral serotonin values ( Limitations of the study include a relatively small non-randomized retrospective clinical sample

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In addition, although mtDNA-mediated CR mutations increase with aging in control healthy brains, the elevation is higher in the brains of AD, Down syndrome (DS), and DS with Alzheimer (DSAD) patients (436)

Acetyl-L- carnitine has been shown to be therapeutic in treatment of this disease [114]