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High EOC MRD was associated with a markedly inferior outcome.[46] The COG AALL1231 study confirmed the prognostic significance of EOC marrow MRD for patients with T-ALL.[142] MRD measurements, in conjunction with other presenting features, have also been used to identify subsets of patients with an extremely low risk of relapse

This structure-based recognition, rather than sequence-based recognition, allows broader flexibility in the protein sequence between SUMO and the protein of interest

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CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices