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Also, it is not clear whether long-term and high-dose use of H 2 would interfere with certain normal cell signaling pathways mediated by reactive oxygen species that we do not fully understand

[250] [251] The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N -oxidation, N -dealkylation, and deamination

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Additionally, flexion foot contractures were graded on a scale of 0-4
