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Besides this, COMT inhibitors are combined with levodopa to prolong its effects and reduce off periods

Nevertheless, experimental data suggest that the altered intracellular redox status associated with hyperhomo-cysteinemia-induced oxidant stress is the major molecular mechanism responsible for the atherothrombogenicity of moderately elevated circulating homocysteine

182 Recently, a Cochrane review tried to draw conclusions from 10 studies with a total of 1,450 participants existing data 183 and made the following points: All studies described the presence of PAEC in 41%78.8% of all patients

The attack of ROS on the polypeptide backbone is initiated by an OH-dependent abstraction of the -hydrogen atom from an amino acid residue to form a carbon-centred radical