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Ca 2+ homeostasis imbalance Upon the release of the excitatory neurotransmitter glutamate from the presynaptic terminal, it initiates the activation of postsynaptic receptors, thereby inducing alterations in the electrical potential across the postsynaptic membrane

The variant that causes chronic hemolysis is uncommon because it is related to sporadic gene mutation rather than the more common inherited gene mutation

While chronic infections with HBV and HCV, heavy alcohol consumption, and diabetes are well-established primary risk factors for HCC, there is compelling and growing evidence that prolonged and active cigarette smoking is an independent and significant risk factor for its development [98, 99]

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