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Description
Next-generation disulfide stapling: Reduction and functional re-bridging all in one

The highly specific interaction of IMC-M113V with cognate pHLA complexes, coupled with its rapid plasma clearance in vivo, particularly at the low doses tested, could explain the absence of serious and/or severe adverse events, including CRS and immune effector cell-associated neurotoxicity syndrome (ICANS) in this study
It is not strictly necessary both have reasonably long half-lives and the synthesis pathway is not a timed reaction requiring simultaneous arrival

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